Introduction of the targeted alpha therapy (with Radium-223) into clinical practice in Japan: learnings and implementation
نویسندگان
چکیده
منابع مشابه
Radium-223 dichloride bone-targeted alpha particle therapy for hormone-refractory breast cancer metastatic to bone
BACKGROUND Hormone-refractory breast cancer metastatic to bone is a clinically challenging disease associated with high morbidity, poor prognosis, and impaired quality of life owing to pain and skeletal-related events. In a preclinical study using a mouse model of breast cancer and bone metastases, Ra-223 dichloride was incorporated into bone matrix and inhibited proliferation of breast cancer ...
متن کاملFirst clinical experience with alpha-emitting radium-223 in the treatment of skeletal metastases.
PURPOSE The main goals were to study the safety and tolerability of the alpha-emitter radium-223 (223Ra) in breast and prostate cancer patients with skeletal metastases. In addition, pain palliation was evaluated. EXPERIMENTAL DESIGN Fifteen prostate and 10 breast cancer patients enrolled in a phase I trial received a single i.v. injection of 223Ra. Five patients were included at each of the ...
متن کاملPatient selection and treatment response assessment in radium-223 therapy
Learning objectives Radium-223 is an alpha emitter, licensed in 2013 for treatment of symptomatic bone metastases in metastatic castration resistant prostate cancer. The treatment consists of 6 intravenous administrations and ongoing patient management before, during and after treatment. In our institution, this service is led by the nuclear medicine department The ALSYMPCA trial, published in ...
متن کاملRadium-223 Chloride
In the last few years, the treatment of castration-resistant prostate carcinoma (CRPC) has changed completely. The approval of docetaxel and subsequent investigation in this field have led to development of new agents that have demonstrated an improvement in overall survival in the post-docetaxel setting, such as cabazitaxel and abiraterone. Radium-223 chloride is a radioisotope that has recent...
متن کاملthe relationship of wtc with communication apprehension and self-perceived communication competene in english and persian context
بیشتر تحقیقات پیشین در زمینه تمایل به برقراری ارتباط به رابطه آن با عوامل فردی چون سن، جنس، نوع شخصیت و... صورت گرفته است. در صورتی که مطالعات کمتری به بررسی رابطه تمایل به برقراری ارتباط زبان آموزان فارسی زبان با ترس از برقراری ارتباط و توانش خود ادراکانه آنها در برقراری ارتباط در محیط فارسی و انگلیسی انجام شده است. بر اساس نظریه الیس (2008) تمایل به برقراری ارتباط جایگاه مهمی در زمینه آموزش م...
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ژورنال
عنوان ژورنال: Annals of Nuclear Medicine
سال: 2018
ISSN: 0914-7187,1864-6433
DOI: 10.1007/s12149-018-1317-1